I Recently had an issue with pops and clicks when playing back audio on my PC using Reason. I was able to solve my problems by upgrading the BIOS and unplugging an external VGA to USB adapter. It turns out that all USB devices compete for the same bandwidth. I ended up using an application called LatencyMon to narrow down the driver that was causing the issue.
LatencyMon
Solving DPC latency issues
PC Optimization