I have been using the send midi clock option in Reason to sync up Reason's tempo to my Line 6 Helix.
It's easy to configure and time based effects like delay and modulation will sync up with the tempo of the song. It's awesome hearing delay trails and modulation times in perfect sync with the DAW.
Here are the steps for syncing Propellerheads Reason to a Line 6 Helix.
In Reason go to Edit > Preferences > Sync. Under Midi Clock Sync select Helix for Output.
Go to Options > Sync > Send Midi Clock.
On your Helix go to Global Settings > MIDI/Tempo > Receive MIDI Clock and select “Auto”
(Helix uses its internal tempo generator until receiving clock from either MIDI or USB). With this setting enabled the Helix will synchronize its time-based effects (such as delay and modulation) to incoming MIDI clock from external DAW software, drum machines, keyboard workstations, or other modelers. When slaved to external MIDI clock, TAP’s scribble strip text grays out and its switch LED ring flashes blue.